Can an Antidepressant Stop Working? Causes, Signs, and Next Steps

Yes, an antidepressant can stop working even after months or years of success. This is a recognized clinical phenomenon, sometimes called antidepressant tachyphylaxis or the “poop-out effect.” It happens when the brain adjusts to a medication over time, causing symptoms to return or treatment benefits to fade despite consistent dosing. It does not mean a […]