TMS for Treatment Resistant Depression

Promising Options for Treatment Resistant Depression

Managing treatment-resistant depression can be challenging, but it is not an impossible task. With effort and perseverance, you and your physician can explore productive solutions like TMS and create a treatment plan that mitigates your symptoms.

What is Treatment-Resistant Depression?


Treatment-resistant depression (TRD) is a type of depression that does not improve with conventional therapies such as antidepressant medication. People with treatment-resistant depression may have attempted several courses of antidepressants or other forms of treatment without seeing a meaningful improvement in their symptoms. It can be a chronic, crippling illness that significantly negatively influences a person’s quality of life.



The signs and symptoms of treatment-resistant depression (TRD) can include:

  • Persistent feelings of sadness, hopelessness, or worthlessness.
  • Lack of interest or pleasure in hobbies that were once enjoyed
  • Difficulty concentrating, remembering, or making decisions
  • Changes in appetite and sleep patterns, such as insomnia or oversleeping
  • Fatigue, loss of energy, or feeling slowed down
  • Thoughts of death or suicide
  • A lack of response to multiple courses of antidepressant medication or other forms of therapy
  • Comorbid conditions such as anxiety, PTSD, and bipolar disorder
  • A history of childhood trauma or abuse.

What Is Treatment Resistant Depression

To qualify as symptoms of treatment-resistant depression, the signs should be persistent and last for at least two weeks or longer. They should also not be due to substance use, medication side effects, or other medical condition.

Battling Treatment-Resistant Depression


Treatment-resistant depression can be difficult to treat. However, it is not necessarily incurable. There are many treatment options available for TRD, and it may take time and experimentation to find the right approach for a particular individual.

While some people may experience complete remission of symptoms with appropriate treatment, others may have ongoing symptoms that can be managed with a combination of medication, therapy, and lifestyle changes. A multidisciplinary approach is often used for TRD, including various medications, psychotherapy, and Transcranial magnetic stimulation (TMS) for severe cases.

Treatments For Treatment-Resistant Depression


There are several treatment options and strategies available for treating treatment-resistant depression, including:


  • Switching to a different class of antidepressants, such as changing from an SSRI to an SNRI or adding a medication like lithium or an atypical antipsychotic.
  • Augmenting therapy, which means adding a medication to a current antidepressant regimen.
  • Combination therapy, which means taking multiple antidepressants at the same time.
  • A trial of ketamine, an anesthetic agent, has shown promising results in treating TRD.


  •  Cognitive Behavioral Therapy (CBT) can help individuals change negative thoughts and behavior.
  • Interpersonal therapy (IPT), which focuses on resolving interpersonal conflicts that may be contributing to depression.

Electroconvulsive Therapy (ECT)


ECT is a procedure that uses electrical impulses to treat severe forms of depression, like treatment-resistant depression. It is usually recommended when other treatments have failed, and the individual’s depression is severe enough to cause them to be at risk of suicide.

Vagus Nerve Stimulation (VNS)


VNS is a procedure involving the implantation of a device that sends electrical impulses to the vagus nerve, a cranial nerve involved in mood regulation. VNS is usually recommended for individuals who have not responded well to other treatments.

Deep Brain Stimulation (DBS)


DBS is a procedure that involves the implantation of electrodes in specific areas of the brain that are involved in mood regulation. It is FDA-approved for TRD treatment.

Transcranial Magnetic Stimulation (TMS)


TMS is a non-invasive technique that stimulates brain nerve cells thought to be involved in mood regulation using magnetic fields. It is used as a treatment for a variety of mental health conditions, including depression and anxiety.

Treatment Resistant Depression Options

How It Works:

  • TMS treatment typically involves daily sessions over several weeks, each lasting about 20-40 minutes.
  • During a TMS session, a magnetic coil is placed against the scalp, and brief pulses of magnetic energy are directed at particular brain regions involving mood regulation, such as the prefrontal cortex.
  • These magnetic pulses generate electrical currents in the brain, which stimulate nerve cells and may help improve mood and cognitive symptoms.


  • TMS is relatively safe and well-tolerated with minimal side effects.
  • The benefits of TMS for treatment-resistant depression include improvement in mood, anxiety, and cognitive symptoms.
  • TMS is extremely useful in reducing symptoms of depression in people who have not responded to other treatments.

Expected Effects:

  • The effects of TMS can vary, but most people experience some degree of improvement in their symptoms.
  • Some people may see improvement in their symptoms after only a few sessions, while others may require more extensive treatment.
  • The improvement in symptoms can be temporary or long-lasting. It’s essential to monitor symptoms and work closely with a healthcare provider to maintain progress.

It’s important to note that each person’s TRD is unique, and the best treatment strategy will vary depending on the individual’s specific needs and circumstances. Usually, a combination of these treatment options may be more effective than a single approach.

Lifestyle Changes To Manage Treatment-Resistant Depression


Patients can make several steps and lifestyle changes to help improve their symptoms and make the most out of their treatment for treatment-resistant depression. Some tips include:

  • Adhere to your treatment plan: It’s important to stick to your treatment plan, whether it includes medication, therapy, or a combination of both. It can be challenging to stay on track, but working closely with your healthcare provider can help ensure that you get the most out of your treatment.
  • Keep in regular contact with your healthcare provider: Regular follow-up appointments with your healthcare provider can help ensure that your treatment plan is working and that any necessary adjustments are made.
Treatment for Treatment Resistant Depression
  • Practice self-care: Taking care of yourself is vital for managing the condition. This may include getting enough sleep, eating a healthy diet, and engaging in regular physical activity.
  • Try mindfulness and relaxation techniques: Mindfulness and relaxation techniques, such as meditation, yoga, or deep breathing exercises, can help reduce stress and improve mood.
  • Seek a support system: Having a support system can help manage TRD. This may include friends, family, or support groups.
  • Practice good sleep hygiene: Establish a regular sleep schedule and avoid electronics before bedtime to get enough sleep, which is essential in managing treatment-resistant depression.
  • Keep a journal: Writing down your thoughts and emotions can help you identify triggers, patterns, and coping mechanisms, enabling you to understand your condition better.
  • Be realistic: TRD can be challenging; thus, setting realistic expectations about treatment outcomes is important. It may take time to find the right treatment approach, and even with the best treatment, some people may continue to experience symptoms.

TRD is a serious mental health condition that can cause long-term distress. Symptoms include persistent sadness, fatigue, changes in appetite, and suicidal thoughts. Fortunately, multiple treatment options are available, including medications, TMS, and various forms of brain stimulation. For best results, it’s important to work with a healthcare provider to find the right treatment plan. Additionally, self-care and lifestyle changes, such as mindfulness and relaxation techniques, can also help manage symptoms.