Brain Stimulation for Depression Options
Brain Stimulation for Depression: 2026 Options

According to a scoping review published in the Journal of Clinical Medicine (July 2026), electroconvulsive therapy and repetitive TMS are the two most evidence-supported brain stimulation therapies for treatment-resistant depression, with TMS increasingly preferred for its comparable efficacy and significantly cleaner side effect profile. That comparison looks very different in 2026 than it did even […]

tms vs dbs​ comparison
TMS vs DBS: Key Differences, Risks & Benefits

According to a comprehensive narrative review published in Brain Sciences (MDPI, November 2025), deep brain stimulation (DBS) demonstrates clinically meaningful symptom reductions across psychiatric conditions, with response and remission rates for depression approaching 48% and 35%, respectively, in patients who had already exhausted every other available treatment. That context is everything. TMS vs DBS is […]

Spravato vs TMS compared
Spravato vs TMS: Which Depression Treatment Is Right for You?

According to a 2025 individual participant data analysis published in eClinicalMedicine (The Lancet), intranasal esketamine does not appear to be more effective than TMS for treatment-resistant depression; TMS was found to be similarly effective, or potentially even superior, to Spravato across key outcomes. That is a striking finding, especially for patients who assume a medication-based […]

TMS vs Ketamine compared
TMS vs Ketamine: Comparing Effectiveness, Side Effects & Use Cases

According to a systematic review and meta-analysis published in the Journal of Affective Disorders (Rakesh et al., August 2024), According to a naturalistic study published in PLOS ONE (PubMed, 2022), both TMS and intramuscular ketamine produced equally significant reductions in depression and anxiety symptoms in treatment-resistant patients, with no statistically meaningful difference in response or […]

comparison of mert vs tms effect on the brain
MeRT vs TMS: Comparing Two Brain-Based Therapies

According to the U.S. Food and Drug Administration, TMS has received FDA clearance for major depressive disorder, obsessive-compulsive disorder, smoking cessation, and anxious depression, while MeRT, as of 2025, has not yet received FDA clearance for any specific condition, with its pivotal PTSD trial still under review (FDA Device Database, 2025). That single fact frames […]